Day 1: Bioinformatic tools for Genome Annotation Part 1: Bioinformatics: what are the tools available? Part 2: Bioinformatic tools for Genome Annotation Hands-on 1: Annotation with the COG database Day 2: Metagenome mining of secondary metabolite biosynthetic gene clusters (SM-BGCs) Study case: the marine bacterial Aquimarina genus Hands-on 3: Metagenome mining of SM-BGCs using antiSMASH and BiG-SCAPE